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Combination therapy is a treatment approach that involves using two or more therapeutic agents or modalities simultaneously to enhance effectiveness and improve patient outcomes. This strategy is commonly employed in the treatment of complex or resistant conditions, such as cancer, HIV/AIDS, and chronic diseases. The goal of combination therapy is to target multiple pathways or mechanisms of action, thereby increasing the likelihood of treatment success and reducing the potential for resistance. For instance, in cancer treatment, combination therapy might involve a mix of chemotherapy, radiation, and targeted therapy to attack cancer cells from different angles and prevent them from developing resistance to a single treatment. Similarly, in HIV/AIDS, antiretroviral therapy (ART) combines multiple drugs to suppress viral replication and prevent the development of drug resistance. The primary cause for using combination therapy is to maximize therapeutic efficacy while minimizing the risk of treatment failure and resistance. By leveraging the strengths of different treatments, combination therapy can often achieve better control of disease and improve overall survival rates. However, combination therapy can also be associated with potential complications. These can include an increased risk of side effects from the cumulative impact of multiple drugs or therapies, such as nausea, fatigue, or immune system suppression. There is also the possibility of drug interactions, where one medication may affect the metabolism or effectiveness of another. Additionally, managing the complexities of multiple treatments can require careful monitoring and adjustments. Despite these challenges, combination therapy remains a vital approach in managing many complex medical conditions, offering improved outcomes and enhanced therapeutic benefits.